The use of corticosteroids in COVID-19

Abstract

In its most severe form, hyperinflammation driven by a dysregulated immune/inflammatory response to SARS-CoV-2 causes acute respiratory distress syndrome, contributing to disease severity and even death. Several therapeutic interventions are currently being investigated to determine treatment strategies based on the stage of disease progression. Corticosteroid therapy targets hyperinflammation, also known as a “cytokine storm”. There are disparities in research findings that probe the benefit of corticosteroids in improving the life expectancy i patients with severe or critical COVID-19. As a result, corticosteroids should be used with caution taking into account the risk-benefit ratio.